Award
National Institute of General Medical Sciences 5R35GM148177-05
Mitochondria and anesthetic-induced developmental neurotoxicity
Recipient
Ohio State University
Award Amount
$388,575.00
Ceiling
$388,575.00
Awarded
July 20, 2026
Identifier
5R35GM148177-05
This award supports research on how anesthetics cause neurotoxicity through mitochondrial dysfunction in developing brains, aiming to develop neuroprotective treatments.
Description
The project investigates mitochondrial functions and regulatory mechanisms in anesthetic-induced neurotoxicity (AIDN) and aims to develop neuroprotective approaches targeting mitochondria. It focuses on mitochondrial signaling in cognitive dysfunction and behaviors, posttranscriptional regulation of mitochondrial signaling, and neuroprotective effects of small molecules using transgenic mouse models and human induced pluripotent stem cell models.