Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R00HD102584-05

Decoding the dynamics and regulation of parental allelic expression at single-cell resolution

The award supports research to understand parental genetic inheritance and its regulation during embryonic development by studying allele-specific gene expression at single-cell resolution using hybrid ascidians. The project involves developing novel approaches to profile gene expression and chromatin accessibility, and applying spatial transcriptomics to dissect gene regulation in the context of cell-cell interactions.

Description

This project aims to elucidate the regulatory mechanisms of allele-specific gene expression during embryonic development using hybrid ascidians, with a focus on single-cell and spatial transcriptomics techniques to understand parental inheritance and gene regulation.

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