Award
National Institute of Dental and Craniofacial Research 5R01DE031452-05
Dissection of the Molecular Basis of Pleiotropy Between GnRH Neuronal Development and Cranial Suture Fusion
Recipient
Massachusetts General Hospital
Award Amount
$790,404.00
Ceiling
$790,404.00
Awarded
June 03, 2026
Identifier
5R01DE031452-05
The project investigates the genetic overlap between reproductive disorders and craniofacial development by studying pleiotropy in human genetic disorders, focusing on shared molecular pathways and novel gene discovery using human and zebrafish models.
Description
This project leverages two developmental genetic conditions, Idiopathic Hypogonadotropic Hypogonadism (IHH) and Craniosynostosis (CS), to study pleiotropy. It aims to define shared molecular pathways, discover novel genes, and analyze phenotypic pleiotropy using human cohorts and zebrafish models.