Award
National Institute of Biomedical Imaging and Bioengineering 5R01EB033172-04
Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound Processing
Recipient
University of Virginia
Award Amount
$668,814.00
Ceiling
$668,814.00
Awarded
June 24, 2025
Identifier
5R01EB033172-04
Award for developing fluorescent indicators to image synaptic zinc in cortical sound processing, led by University of Virginia researchers, with a focus on neurological disorders and sensory processing.
Description
The project focuses on developing new technology for imaging synaptic Zn2+ secretion in awake animals. The project aims to study the roles of Zn2+ in cortical sound processing. The project will develop genetically encoded Zn2+ indicators (GEZIs) and integrate them with ZnT3 conditional knockout mice. The project is led by Dr. Huiwang Ai and Dr. Thanos Tzounopoulos. The project emphasizes public health relevance related to neurological disorders and sensory processing.