# NIH Reporter #11263857

Research Project 2: Biomaterial-driven CAR T cell generation for treatment of GBM

**Recipient:** UNIV OF NORTH CAROLINA CHAPEL HILL

**Award Amount:** $370,392.00
**Ceiling:** $370,392.00

**Awarded:** March 05, 2026

**Identifier:** 11263857

This award funds a research project by the University of North Carolina Chapel Hill to develop biomaterial-driven CAR T cell therapy for glioblastoma multiforme (GBM). The project includes manufacturing, in vivo testing, and safety evaluation over approximately 5 years with a total award amount of $370,392.

### Description

The project aims to develop a platform for CAR T cell manufacturing using a biomaterial scaffold. The project involves in vivo generation of CAR T cells, phenotypic and functional characterization, and safety testing. The project emphasizes innovation in GBM treatment and expanding patient access to CAR T therapy.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11263857)