Award
National Heart, Lung, and Blood Institute 5R01HL166617-04
Coronary artery dysfunction in OSA: Role of mineralocorticoid receptors
Recipient
University of Missouri-Columbia
Award Amount
$586,392.00
Ceiling
$586,392.00
Awarded
May 11, 2026
Identifier
5R01HL166617-04
NIH-funded research project investigating the role of mineralocorticoid receptors in coronary artery dysfunction caused by obstructive sleep apnea, aiming to identify therapeutic interventions.
Description
Research project to characterize the impact of obstructive sleep apnea (OSA) on coronary arteries in female and obese patients, focusing on mineralocorticoid receptor activation using a mouse model. The study evaluates MR signaling in OSA-mediated coronary artery dysfunction and explores potential therapeutic targets including MR antagonists such as spironolactone and finerenone.