Award
National Heart, Lung, and Blood Institute 5R01HL163092-04
Desmoplakinopathies: Integrated Pathophysiology and Therapeutics
Recipient
Yale University
Award Amount
$660,080.00
Ceiling
$660,080.00
Awarded
March 27, 2026
Identifier
5R01HL163092-04
The NIH grant supports research on the molecular mechanisms of DSP mutations and exercise in ACM, focusing on genetic and pharmacological interventions to prevent DSP degradation and disease progression.
Description
This project investigates calpain-mediated Desmoplakin (DSP) degradation and its exacerbation by exercise in Arrhythmogenic Cardiomyopathy (ACM), aiming to develop targeted therapies to mitigate sudden cardiac death risk in DSP mutation carriers.