Award
National Cancer Institute 5R01CA281285-03
Optimizing immunoradiotherapy for HNSCC
Recipient
University of California, San Diego
Award Amount
$663,994.00
Ceiling
$663,994.00
Awarded
August 15, 2025
Identifier
5R01CA281285-03
NIH grant awarded to University of California, San Diego to optimize immunoradiotherapy for HPV-negative head and neck squamous cell carcinoma by studying the role of sentinel lymph nodes and improving immune response treatments.
Description
This NIH grant project aims to elucidate the role of draining sentinel lymph nodes in anti-tumor immune responses, optimize immune therapies in head and neck squamous cell carcinoma (HNSCC), and improve patient outcomes through strategic treatment planning. The project focuses on using animal models and clinical trials to maximize immunotherapy responses by optimizing treatment sequencing, radiation targeting, and enhancing antigen presentation in draining lymph nodes.