Award
NIH Reporter #11279729
Molecular Mechanism of Human Myogenesis
Recipient
University of Georgia
Award Amount
$614,390.00
Ceiling
$614,390.00
Awarded
May 01, 2026
Identifier
11279729
NIH grant awarded to University of Georgia to study the molecular mechanism of human myogenesis, focusing on CHAMP1 gene's role in muscle development and disease, aiming to develop new therapies.
Description
This project aims to elucidate CHAMP1’s role in muscle development and disease, identify molecular targets, and develop new treatment strategies. It involves investigating CHAMP1’s role in muscle development, focusing on its regulation of Myomaker and interaction with the MyoD:TCF12:P300 complex, using techniques such as RNA sequencing, CUT&Tag, structural modeling, and spatial transcriptomics. The goal is to develop animal models and molecular targets for therapy, including gene therapy and drug development.