NIH Reporter #2R01GM132672-05

The ion channel TRPA1 is required for suppression of inflammation

NIH grant awarded to the Feinstein Institute for Medical Research to study the role of TRPA1 ion channel in inflammation suppression, aiming to identify neural circuits that regulate inflammation and develop new treatment strategies.

Description

This NIH grant supports research to understand how the brain processes sensory signals and regulates inflammation, focusing on the role of the ion channel TRPA1 in suppressing inflammation and cytokine storms. The project uses genetic, bioelectronic, and chemogenetic approaches to map brain neural networks activated by vagus TRPA1 signaling and assess their impact on inflammation.

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