Award
NIH Reporter #5R01HL174591-02
Defining the molecular basis of thrombospondin-1-induced fibro-fatty diaphragm remodeling--a driver of obesity-associated respiratory dysfunction
Recipient
University of Michigan at Ann Arbor
Award Amount
$508,240.00
Ceiling
$508,240.00
Awarded
September 01, 2026
Identifier
5R01HL174591-02
NIH grant awarded to study how thrombospondin-1 affects diaphragm remodeling and respiratory dysfunction in obesity, using mouse models and human studies.
Description
This NIH grant aims to investigate the cellular and molecular mechanisms underlying obesity-induced respiratory dysfunction, with a focus on thrombospondin-1 (THBS1) and its role in diaphragm remodeling. The project involves cell culture, genetically engineered mouse models, and human cohort analysis.