Award
National Institute on Aging 1R21AG095557-01
Targeting LARP6 in aging-associated heart failure
Recipient
University of Missouri-Columbia, Columbia, MO, United States
Award Amount
$429,394.00
Ceiling
$429,394.00
Awarded
December 12, 2025
Identifier
1R21AG095557-01
This award funds research to target LARP6 protein to treat aging-associated heart failure characterized by cardiac fibrosis and reduced capillary density, using genetic and pharmacological approaches.
Description
The project investigates the role of LARP6 in cardiac fibrosis and vasculature in aging-associated heart failure with preserved ejection fraction (HFpEF), using genetic mouse models and small molecule inhibitors, with endpoints including cardiac morphology, function, fibrosis, capillary density, and gene expression. The research aims to evaluate LARP6 as a druggable target for treating aging-associated HFpEF using genetic and pharmacological models.