Award
National Institute of Allergy and Infectious Diseases 5R01AI185073-02
Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
Recipient
Albert Einstein College of Medicine
Award Amount
$585,670.00
Ceiling
$585,670.00
Awarded
July 15, 2025
Identifier
5R01AI185073-02
This NIH-funded research grant supports a project to investigate the glycoprotein functions of the Crimean-Congo hemorrhagic fever virus to understand its assembly, entry, and pathogenesis, aiming to develop new therapeutic strategies.
Description
The project aims to study the glycoprotein functions of the Crimean-Congo hemorrhagic fever virus (CCHFV), a severe and often lethal hemorrhagic disease endemic in Europe, Asia, and Africa. The research will focus on the architecture, assembly, and functions of glycoprotein complexes involved in virion assembly, entry, and pathogenesis. The team includes experts in structural virology, virus-host interactions, and mass spectrometry. The goal is to identify viral vulnerabilities for developing medical countermeasures.