Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 3R01HD112302-04S1
Microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children
Recipient
Massachusetts General Hospital
Award Amount
$259,027.00
Ceiling
$259,027.00
Awarded
April 02, 2026
Identifier
3R01HD112302-04S1
NIH awarded $259,027 to Massachusetts General Hospital for a research project studying microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children, using multi-omics approaches and longitudinal cohort data.
Description
This NIH-funded research project focuses on microbiome and immune development in HIV-exposed children. It aims to compare gut microbiome development in children with and without HIV exposure and growth stunting, define maternal and child antibody response profiles to enteric organisms, and link gut microbiome profiles to immune changes in growth-stunted children using a multi-omics approach. The project leverages biobanked and newly collected samples from a longitudinal birth cohort in Uganda and uses integrated multi-omics to identify mechanisms of growth stunting and immune development.