Award
National Institute of Biomedical Imaging and Bioengineering 5R01EB033821-03
Synthetic vascularization and regeneration in engineered tissues
Recipient
Boston University (Charles River Campus)
Award Amount
$535,365.00
Ceiling
$535,365.00
Awarded
July 29, 2025
Identifier
5R01EB033821-03
This NIH grant funds research to develop tools for controlling blood vessel growth and tissue expansion in engineered liver tissues using synthetic biology, aiming to improve organ grafts for clinical use.
Description
The project aims to engineer liver tissue grafts with controllable vascularization and expansion in vivo, leveraging synthetic transcription factors to regulate paracrine signaling within engineered tissues. The goal is to develop methods for functional vasculature formation, on-demand tissue growth, and system robustness in suboptimal environments, advancing tissue engineering toward clinical applications.