Award
NIH Reporter #5K99NS144382-02
A novel role for cell cycle regulators in oligodendrogenesis and myelination
Recipient
Oregon Health & Science University, Portland, OR
Award Amount
$126,122.00
Ceiling
$126,122.00
Awarded
July 24, 2026
Identifier
5K99NS144382-02
Research project investigating the role of Cyclin Y-like 1 (CCNYL1) in oligodendrocyte differentiation and myelination to uncover molecular mechanisms and potential therapies for demyelinating diseases such as multiple sclerosis.
Description
This research aims to understand how a cell cycle protein called CCNYL1 is used by oligodendrocytes to develop and create myelin, the insulation around nerve fibers that allows efficient communication in the nervous system. The work could lead to new therapies for demyelinating diseases like multiple sclerosis.