Award
NIH Reporter #5K23NS140543-02
Dissecting the Heterogeneous Molecular Mechanisms Underlying Multiple Sclerosis Progression
Recipient
University of California, San Francisco
Award Amount
$198,928.00
Ceiling
$198,928.00
Awarded
August 18, 2026
Identifier
5K23NS140543-02
This NIH grant funds a project to analyze serum proteins to understand molecular mechanisms underlying multiple sclerosis progression, focusing on different disease stages and types of disability accumulation.
Description
The project aims to perform a proteome-wide analysis of serum samples from US and German cohorts using the Olink® Explore HT kit to measure up to 5400 proteins. The analysis will focus on CNS-driven markers to determine the magnitude of astrocyte response, severity and dynamics of oligodendrocyte and myelin injury, and the role of synaptic injury during pre-progression. The dataset will be further analyzed to define mechanisms of PIRA at different disease stages, differences from RAW, and markers characterizing each process.