Award
NIH Reporter #5R35GM148160-04
Cell and mechanobiology of Asymmetric Cell Division
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$376,659.00
Ceiling
$376,659.00
Awarded
December 19, 2025
Identifier
5R35GM148160-04
Research project studying asymmetric cell division mechanisms in Drosophila neuroblasts to understand neurodevelopmental disorders and cancer.
Description
This project investigates asymmetric cell division (ACD) in Drosophila neuroblasts, focusing on cortical flows, cell size asymmetry, centrosome asymmetry, and their roles in cell fate decisions. The research employs live cell imaging, superresolution microscopy, RNA sequencing, and optogenetics to explore mechanisms underlying ACD and its implications for neurodevelopmental disorders and cancer.