Award
NIH Reporter #5R21AI185033-02
Role of APOBEC3B in the Innate Immune Response
Recipient
University of California-Irvine, Irvine, CA, United States
Award Amount
$196,250.00
Ceiling
$196,250.00
Awarded
December 16, 2025
Identifier
5R21AI185033-02
This award funds research to investigate the antiviral functions of APOBEC3B, focusing on its role in innate immunity and suppression of RNA virus replication through mechanisms beyond its known deaminase activity.
Description
Understanding how APOBEC3B inhibits RNA virus replication and its role in innate immunity. This project aims to elucidate the antiviral functions of APOBEC3B beyond its deaminase activity, including its role as a viral RNA sensor and its modulation of immune pathways.