Award
NIH Reporter #3U01HG012059-05S1
The impact of genomic variation on environment-induced changes in pancreatic beta cell states
Recipient
University of California, San Diego, La Jolla, CA
Award Amount
$1,155,954.00
Ceiling
$1,155,954.00
Awarded
July 27, 2026
Identifier
3U01HG012059-05S1
A research project funded by the National Human Genome Research Institute to study how genomic variation affects pancreatic beta cell states in response to environmental signals, using advanced single cell multiomic assays and machine learning.
Description
This project aims to develop gene regulatory network models from single cell multiomic data to predict relationships among genomic elements, genes, and phenotypes. Measurements will be taken across nine secretory signals and four time points, using paired assays. Machine learning will infer relationships, and models will be validated via CRISPR interference and allele-specific gene editing. The outcomes will enhance understanding of genomic regulation dynamics in a responsive cell type.