Award
National Institute of Mental Health 1R21MH137593-01A1
Characterizing the role of ventral pallidal astrocytes in approach/avoidance conflict
Recipient
University of Puerto Rico Med Sciences
Award Amount
$409,750.00
Ceiling
$409,750.00
Awarded
April 01, 2025
Identifier
1R21MH137593-01A1
Research project funded by the National Institute of Mental Health to study how ventral pallidal astrocytes affect approach/avoidance conflict behaviors in mice, with implications for mental health disorders.
Description
This project aims to characterize the role of ventral pallidal astrocytes in influencing approach/avoidance conflict behaviors in mice, using fiber photometry and chemogenetic manipulations in the platform-mediated avoidance task. The study will shed light on how astrocytes mediate approach/avoidance conflict by regulating key synapses, which is significant for understanding anxiety, depression, and addiction.