Award
NIH Reporter #11438326
Dissecting Oxygen Sensing and PTEN Loss in FDG/Fluciclovine Uptake as Markers of PSMA Radioligand Therapy Resistance
Recipient
Dana-Farber Cancer Inst
Award Amount
$170,639.00
Ceiling
$170,639.00
Awarded
August 24, 2026
Identifier
11438326
This award funds a research project investigating resistance mechanisms in PSMA radioligand therapy for prostate cancer, aiming to develop imaging markers and therapeutic strategies to improve treatment outcomes.
Description
Research project on PSMA radioligand therapy resistance focusing on mechanisms of resistance in PSMA radioligand therapy for prostate cancer, emphasizing spatial biology, image analysis, and PET analytics. The project prioritizes human tissues, organoids, and cell-based assays, with limited vertebrate animal studies. It aims to develop imaging markers and therapeutic strategies to reduce treatment failure.