Award
National Cancer Institute 4R01CA280833-04
Unlocking the Chemical Space of Cancer-Associated Perturbations
Recipient
University of Pennsylvania
Award Amount
$863,577.00
Ceiling
$863,577.00
Awarded
August 25, 2025
Identifier
4R01CA280833-04
NIH awarded a research grant to University of Pennsylvania to develop a chemical biology platform for profiling tumor proteomes to advance precision oncology.
Description
The project aims to develop the Probe Enabled Activity Reporting (PEAR) platform to profile tumor proteomes using chemical biology approaches. This platform will help understand proteomic changes in cancer cells, identify therapeutic targets, and inform targeted therapy development. The research focuses on the molecular complexity of tumor biology, integrating chemical probes to visualize and identify protein targets before and after treatment, with the goal of advancing precision oncology.