Award
NIH Reporter #1R01AI194356-01
Bacterial cell wall remodeling, innate immunity, and pathogenesis
Recipient
University of Illinois at Chicago
Award Amount
$2,841,668.00
Ceiling
$2,841,668.00
Awarded
July 07, 2025
Identifier
1R01AI194356-01
NIH funded project studying the role of Staphylococcus aureus peptidoglycan processing in immune response and pathogenesis, focusing on IL-1β maturation and SagB enzyme.
Description
This project investigates how peptidoglycan processing by Staphylococcus aureus, particularly via the enzyme SagB, influences IL-1β maturation and inflammatory pathology. The study aims to elucidate mechanisms of immune recognition and how SagB promotes infection, potentially revealing new therapeutic targets.