Award
National Institute on Minority Health and Health Disparities 5U54MD007590-39
Epigenetic Silencing of Inhibitor of Differentiation 4 (ID4) Promotes Stem Cell and Castration Resistant Phenotype in Prostate Cancer
Recipient
Clark Atlanta University, Atlanta, GA, United States
Award Amount
$107,838.00
Ceiling
$107,838.00
Awarded
June 30, 2026
Identifier
5U54MD007590-39
Research project funded by NIMHD to study how epigenetic silencing of ID4 influences prostate cancer progression and resistance, aiming to develop new therapeutic approaches.
Description
This project investigates the role of ID4 in prostate cancer, focusing on how its epigenetic silencing promotes stem cell properties and castration resistant phenotype. The research aims to understand the molecular mechanisms by which loss of ID4 affects androgen receptor activity and contributes to aggressive prostate cancer growth, with the goal of developing combinatorial therapeutic strategies targeting these pathways.