Award
National Institute of General Medical Sciences 5R35GM151249-03
Understanding the OAS/RNase L pathway during pathogenic viral infections
Recipient
University of Florida, Gainesville, FL
Award Amount
$483,000.00
Ceiling
$483,000.00
Awarded
July 14, 2025
Identifier
5R35GM151249-03
This award funds research to understand the RNase L pathway's role in antiviral defense and viral evasion, aiming to advance antiviral and cancer therapies.
Description
Ribonuclease L (RNase L) is a key component of the mammalian innate antiviral response. It degrades cellular mRNAs upon activation, reprograms translation, inhibits nuclear mRNA export, and regulates the assembly of antiviral ribonucleoprotein complexes. The research aims to characterize how RNase L functions and how viruses evade or hijack this pathway, with implications for antiviral, immunomodulatory, and anticancer therapies.