Award
National Institute of General Medical Sciences 2R15GM140422-02
Tunable Protein Linkers as Therapeutic Targets: Structural Insights from Palladin Ig Domains
Recipient
Wichita State University
Award Amount
$509,538.00
Ceiling
$509,538.00
Awarded
July 24, 2026
Identifier
2R15GM140422-02
Research project investigating how interdomain linker regions affect protein structure and function, aiming to advance understanding of cytoskeletal regulation and support biomedical innovation. Conducted at Wichita State University with undergraduate involvement.
Description
This project will elucidate how interdomain linker regions regulate the structural and mechanical properties of multidomain proteins. By defining how sequence and conformational dynamics influence protein stability and function, the work will provide insight essential for understanding cytoskeletal regulation in health and disease. The resulting mechanistic knowledge will inform strategies for engineering proteins with tailored mechanical and functional properties relevant to biomedical research and therapeutic innovation.