Award
National Institute of General Medical Sciences 5R35GM133600-07
Repetitive sequences drive genome variation and plasticity
Recipient
University of Connecticut School of Medicine, Farmington, CT, United States
Award Amount
$515,169.00
Ceiling
$515,169.00
Awarded
January 07, 2026
Identifier
5R35GM133600-07
The award supports research on how repetitive DNA sequences contribute to genome variation and stability, focusing on transposable elements and their impact on gene regulation and genomic integrity in mammals.
Description
This project investigates the role of transposable elements and other large repeats in generating genomic variation, diversifying transcriptomes, and changing the regulatory landscape of closely related species. It aims to identify repeat-mediated rearrangements, investigate transposon-driven gene regulation diversification, and identify genomic guardians of stability in mouse and human genomes.