Award
NIH Reporter #5R01HL157587-04
Heparin-free extracorporeal circulation via combined nitric oxide releasing/generating surfaces
Recipient
University of Georgia, Athens, GA, United States
Award Amount
$370,870.00
Ceiling
$370,870.00
Awarded
May 29, 2024
Identifier
5R01HL157587-04
Research grant to develop a multifunctional polymer coating that releases and generates nitric oxide to prevent thrombosis and infection in blood-contacting medical devices, enabling heparin-free extracorporeal circulation.
Description
The project aims to develop and evaluate a novel polymer coating that combines nitric oxide (NO) release and NO generation to prevent platelet adhesion, activation, thrombosis, and microbial biofilm formation on blood-contacting devices. This technology seeks to enable extracorporeal circulation (ECC) without the need for heparinization, reducing bleeding risks and improving patient outcomes.