Award
National Institute of Allergy and Infectious Diseases 5R21AI186960-02
The proinflammatory functions of granzymes and their impact on endothelial inflammation/injury
Recipient
Georgetown University
Award Amount
$195,000.00
Ceiling
$195,000.00
Awarded
June 09, 2025
Identifier
5R21AI186960-02
NIH awarded a research grant to study the proinflammatory functions of granzymes and their impact on endothelial inflammation and injury, particularly in the context of HIV infection and cardiovascular disease risk.
Description
This is a multi-year NIH research grant focusing on HIV, cardiovascular disease, and immune mechanisms. The project investigates the mechanisms driving vascular damage/inflammation during HIV infection, focusing on extracellular granzymes secreted by CD8 T cells that promote endothelial inflammation and the blockade of this pathway to reduce vascular inflammation and cardiovascular risk.