Award
NIH Reporter #5R35GM136363-07
Circadian regulation of cell outputs
Recipient
New York University, NY, United States
Award Amount
$481,723.00
Ceiling
$481,723.00
Awarded
April 03, 2026
Identifier
5R35GM136363-07
This award funds research on the molecular mechanisms underlying circadian regulation of neuronal structure and function, with implications for understanding sleep, neurodevelopmental disorders, and neural plasticity.
Description
The project aims to identify and study novel molecular mechanisms of neuronal plasticity, focusing on circadian clock neurons as models with highly predictable plasticity. It investigates control of cell size and shape in Drosophila s-LNv circadian pacemaker neurons, focusing on gene expression pathways activated by neuronal inactivity, the role of Pura as a GEF, and cell adhesion molecules involved in neural connectivity.