Award
National Institutes of Health 1F30AI197455-01
Understanding the mechanisms behind complement mediated synapse elimination in neuroinflammatory disease
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$34,848.00
Ceiling
$34,848.00
Awarded
April 22, 2026
Identifier
1F30AI197455-01
Research project focused on understanding the role of complement molecules C1q and C3 in neuroinflammation and synapse loss in Multiple Sclerosis, aiming to develop therapeutic strategies.
Description
The project aims to understand how the complement molecule C1q influences neurodegeneration and neuroinflammation in Multiple Sclerosis (MS). It investigates the role of microglia-derived C1q in propagating neuroinflammation and inducing astrocytes to secrete C3, which is necessary for synapse loss. The study will evaluate the role of C1q and C3 using molecular genetic tools and antisense oligonucleotides (ASOs) to potentially rescue synapses and reduce neuroinflammation.