Award
National Institute of Dental and Craniofacial Research 5R01DE031261-05
Integration of polygenic risk and facial morphometrics to decipher the genetic susceptibility of orofacial clefting
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$755,044.00
Ceiling
$755,044.00
Awarded
January 13, 2026
Identifier
5R01DE031261-05
A research project funded by the National Institute of Dental and Craniofacial Research to study genetic risk factors and facial morphometrics related to orofacial clefting using a diverse cohort, aiming to improve understanding and treatment of OFC.
Description
This project leverages a large diverse orofacial cleft (OFC) cohort from 5 ethnic groups to study genetic risk factors and perform gene discovery. It explores the genetic influence of 3D facial variation on OFC, aiming to expand understanding of genetic risk factors across populations and discover new genes associated with OFC, with potential applications in prenatal screening, genetic counseling, and treatments.