Award
NIH Reporter #5R01AR081228-05
To explore the molecular and cellular effects of transient DUX4 expression in skeletal muscle
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$323,950.00
Ceiling
$323,950.00
Awarded
August 14, 2026
Identifier
5R01AR081228-05
This award funds research to study the effects of transient DUX4 expression in skeletal muscle and its role in facioscapulohumeral muscular dystrophy, focusing on molecular, cellular, and epigenetic changes using mouse models.
Description
The project aims to understand the molecular and cellular effects of transient DUX4 expression in skeletal muscle, particularly its role in facioscapulohumeral muscular dystrophy (FSHD). It investigates whether transient DUX4 expression can trigger degenerative processes or set up a pro-degenerative state that, combined with injury, leads to muscle dystrophy. The research involves studying long-term effects of DUX4 expression, muscle pathology, and epigenetic changes using mouse models.