Award
NIH Reporter #2R01AI089956-11
Congenital CMV and CNS Infection Mechanisms of Protective Immunity
Recipient
University of Alabama at Birmingham, Birmingham, AL, United States
Award Amount
$2,012,428.00
Ceiling
$2,012,428.00
Awarded
August 03, 2026
Identifier
2R01AI089956-11
Research project funded by NIAID to study mechanisms of CNS infection and immunity in congenital CMV using a mouse model, aiming to improve understanding and interventions for neurodevelopmental disorders caused by cCMV.
Description
This project aims to characterize early events of CNS infection, the role of antiviral antibodies in modifying viral entry, the control of CNS infection by innate immune responses, and mechanisms of altered cerebellar development following virus-induced inflammation. Results will enhance understanding of neurodevelopmental disorders associated with congenital cytomegalovirus (cCMV) and identify strategies to limit long-term CNS sequelae.