Award
National Cancer Institute 5R01CA248317-05
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
Recipient
Jackson Laboratory, Bar Harbor, ME, United States
Award Amount
$502,751.00
Ceiling
$502,751.00
Awarded
December 18, 2024
Identifier
5R01CA248317-05
This NIH grant supports research on MYC-regulated RNA splicing mechanisms in cancer to discover therapeutic targets and biomarkers, focusing on tumor growth driven by MYC oncogene.
Description
The project aims to identify proteins controlling RNA splicing impacted by the MYC oncogene to develop novel therapeutic strategies targeting RNA splicing in tumors and new markers for clinical diagnosis. The research involves characterizing MYC-regulated splicing factors and isoforms that drive tumor growth, with a focus on breast cancer and pan-cancer signatures.