Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK137812-03
Investigating Endocytic Mechanisms in Lysosome Rich Enterocytes
Recipient
Duke University
Award Amount
$555,595.00
Ceiling
$555,595.00
Awarded
July 07, 2026
Identifier
5R01DK137812-03
This award funds research at Duke University to study endocytic mechanisms in lysosome rich enterocytes using zebrafish models, aiming to understand protein absorption relevant to human gut physiology and infant nutrition.
Description
The project aims to investigate mechanisms regulating endocytosis in Lysosome Rich Enterocytes (LREs) in zebrafish. These studies will provide insights into protein absorption mechanisms in the vertebrate gut, relevant for human intestinal physiology, especially infant nutrition and development. The research focuses on elucidating the cellular mechanisms of high-capacity luminal protein uptake mediated by a specialized form of clathrin-mediated endocytosis.