Award
National Institute on Drug Abuse 5R01DA054526-05
Modeling HIV Microglia-Associated Infection and Inflammation in a Chimeric Mouse Brain
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, USA
Award Amount
$749,597.00
Ceiling
$749,597.00
Awarded
June 23, 2025
Identifier
5R01DA054526-05
A research project funded by the National Institute on Drug Abuse to study HIV infection and inflammation in microglia using a chimeric mouse brain model, aiming to develop therapies targeting neuroinflammation and HIV reservoirs.
Description
This project aims to study cell-specific HIV signatures, including genome integration and transcriptomic/epigenomic alterations in microglia within the human postmortem brain, using a mouse model. The research will focus on neuroinflammation, cognition, and reward behavior in mice treated with cART and cannabinoid receptor 2 agonists, to develop experimental therapies and interventions.