Award
National Institute of General Medical Sciences 5R35GM160181-02
Distinct responses to hypoxia in striated muscle
Recipient
University of Wyoming
Award Amount
$355,972.00
Ceiling
$355,972.00
Awarded
July 23, 2026
Identifier
5R35GM160181-02
This award funds research to understand how different striated muscles respond to low oxygen conditions, using new models and tools to study hypoxia sensing and signaling mechanisms.
Description
The project investigates how different types of striated muscle respond to hypoxia, focusing on skeletal, right ventricular (RV), and left (LV) cardiac muscles. It aims to understand hypoxia sensing, signaling mechanisms, and the systemic physiological interactions during low oxygen conditions. The study will develop transgenic mouse models, utilize novel hypoxia quantification tools, and employ ex vivo approaches to dissect responses at the systems level.