Award
NIH Reporter #1R21AG101899-01
L1 retrotransposon contribution to normal brain aging and Alzheimers Disease in vivo
Recipient
Tulane University of Louisiana
Award Amount
$420,750.00
Ceiling
$420,750.00
Awarded
August 31, 2026
Identifier
1R21AG101899-01
A research project funded by the National Institute on Aging to study the impact of L1 retrotransposon activity on brain aging and Alzheimer's Disease progression using mouse models, with potential implications for understanding neurodegeneration.
Description
This project investigates the role of L1 retrotransposons in brain aging and Alzheimer’s Disease using mouse models, aiming to identify potential genetic contributors to neurodegeneration. The study will test whether chronic L1 transgene expression accelerates normal brain aging and the contribution of L1 expression to Alzheimer’s Disease progression.