Award
National Institute of Allergy and Infectious Diseases 5R01AI194499-02
Role of Tregs in the acquisition and maintenance of Tconv anergy in transplantation tolerance
Recipient
University of Chicago
Award Amount
$766,265.00
Ceiling
$766,265.00
Awarded
June 23, 2026
Identifier
5R01AI194499-02
NIH awarded a research grant to the University of Chicago to study how regulatory T cells contribute to transplantation tolerance by inducing anergy in alloreactive T cells, aiming to improve transplant outcomes and reduce immunosuppression side effects.
Description
This NIH research grant focuses on the role of regulatory T cells (Tregs) in programming and maintaining anergy in alloreactive conventional T cells (Tconvs) to promote donor-specific transplantation tolerance. The project aims to elucidate mechanisms by which Tregs induce T cell anergy during transplantation tolerance induction and maintenance, with implications for transplantation, autoimmunity, and cancer.