Award
NIH Reporter #1R21AI196968-01
Molecular Mechanisms Governing Non-canonical miR-146a Biogenesis
Recipient
Beckman Research Institute/City of Hope, Duarte, CA, United States
Award Amount
$489,500.00
Ceiling
$489,500.00
Awarded
February 05, 2026
Identifier
1R21AI196968-01
Research project funded to study the regulation of microRNA-146a by EPRS1 and other proteins to develop therapeutic strategies for inflammatory diseases.
Description
This research aims to uncover how immune cells regulate microRNA-146a, a key anti-inflammatory molecule. Preliminary studies identified the tRNA synthetase EPRS1 as a regulator of miR-146a biogenesis, linking protein synthesis machinery to inflammation control. The project will define how EPRS1 interacts with miR-146a and identify additional regulators using CRISPR screening.