Award
National Institute of Allergy and Infectious Diseases 1R01AI196739-01
Elucidating Treg defects in ALS
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$823,143.00
Ceiling
$823,143.00
Awarded
February 06, 2026
Identifier
1R01AI196739-01
This NIH grant supports research to understand and correct regulatory T cell dysfunction in ALS, aiming to slow disease progression through therapeutic interventions.
Description
The project focuses on understanding and addressing Treg dysfunction in ALS. It aims to elucidate mechanisms of Treg dysfunction, explore gene expression, and test therapeutic interventions such as low-dose IL-2 to restore Treg function. The goal is to identify therapeutic targets and interventions that could enhance Treg function in ALS to slow disease progression.