Award
National Institute of Neurological Disorders and Stroke 11361679
Spreading Depolarization and Progression of Developmental Epileptic Encephalopathy
Recipient
Baylor College of Medicine, Houston, TX
Award Amount
$400,000.00
Ceiling
$400,000.00
Awarded
March 30, 2026
Identifier
11361679
NIH funded project studying spreading depolarization's role in Dravet syndrome epilepsy progression using a mouse model, aiming to understand physiological and behavioral impacts and regulation, with potential broader applications.
Description
This project investigates the role of spreading depolarization (SD) in the genetic epilepsy mouse model of Dravet syndrome. It aims to understand how SD affects physiology and behavior, and how it is regulated. The project will investigate the contribution of SD to epilepsy comorbidities and disease progression in Dravet syndrome using a well-established mouse model, examining correlations with cardiorespiratory instability, neurobehavioral deficits, and hippocampal SD during early-life hyperthermic seizures. Methods developed may apply to other epilepsy models and SD-related pathologies such as stroke, traumatic brain injury, and migraine with aura.