Award
National Institute of Allergy and Infectious Diseases 5R21AI186960-02
The proinflammatory functions of granzymes and their impact on endothelial inflammation/injury
Recipient
Georgetown University, Washington, DC
Award Amount
$195,000.00
Ceiling
$195,000.00
Awarded
June 09, 2025
Identifier
5R21AI186960-02
The study investigates how granzymes secreted by CD8 T cells contribute to vascular inflammation and injury in HIV-infected patients, aiming to reduce cardiovascular risk by blocking this pathway.
Description
This project aims to investigate the underlying mechanisms driving vascular damage and inflammation during HIV infection by focusing on extracellular granzymes secreted by CD8 T cells that promote endothelial inflammation and the blockade of this pathway to reduce vascular inflammation and cardiovascular risk.