Award
NIH Reporter #7U01CA288665-02
Impact of preanalytical conditions on functional cancer biomarkers
Recipient
Not specified
Award Amount
$406,351.00
Ceiling
$406,351.00
Awarded
January 29, 2026
Identifier
7U01CA288665-02
Award for research on optimizing pre-analytic tumor handling to improve functional cancer biomarker accuracy, focusing on RUDBP for personalized ovarian cancer therapy.
Description
This project aims to identify optimal pre-analytic tumor handling conditions for functional cancer biomarkers, specifically focusing on ramp up dynamic BH3 profiling (RUDBP). The study involves measuring how pre-analytic handling alters RUDBP using human surgical resections and patient-derived xenografts. The goal is to develop standard protocols to increase the accuracy and reproducibility of these biomarkers, ultimately aiding in personalized therapy for ovarian cancer patients.