Award
National Institute of Allergy and Infectious Diseases 5R01AI174276-03
Eliminating the Immunogenicity of AAV Vectored HIV Antibody Delivery
Recipient
Massachusetts General Hospital
Award Amount
$819,586.00
Ceiling
$819,586.00
Awarded
December 29, 2025
Identifier
5R01AI174276-03
NIH awarded a grant to Massachusetts General Hospital to engineer AAV vectors that reduce immunogenicity for delivering HIV-neutralizing antibodies, advancing HIV prevention and therapy.
Description
This project aims to determine the mechanisms of immune response development against AAV vectors delivering broadly neutralizing antibodies (bNAbs) for HIV. It involves engineering novel AAV capsids to avoid immune stimulation, dissecting immune responses at the single-cell level, and testing next-generation antibodies in animal models.