Award
National Institute of General Medical Sciences 5R21GM155773-02
Improving the Sensitivity and Selectivity of Laser Desorption Ionization Using N-Heterocyclic Carbene Mass Ionization Tags
Recipient
UNIVERSITY OF NOTRE DAME
Award Amount
$194,699.00
Ceiling
$194,699.00
Awarded
July 23, 2025
Identifier
5R21GM155773-02
This NIH grant supports research to enhance laser desorption ionization techniques using novel chemical tags to improve detection of disease biomarkers.
Description
The project focuses on developing a chemical platform employing N-heterocyclic carbenes and gold nanoparticles to improve ionization efficiency of peptides. The goal is to reveal new disease biomarkers and provide a protein-level view of cellular functions.