Award
NIH Reporter #1K99DA064781-01A1
Determining the role of myelin and oligodendrocytes in fentanyl withdrawal-induced negative affect
Recipient
Washington University, Saint Louis, MO
Award Amount
$165,915.00
Ceiling
$165,915.00
Awarded
July 27, 2026
Identifier
1K99DA064781-01A1
Research project funded by the National Institute on Drug Abuse to study the role of myelin and oligodendrocytes in fentanyl withdrawal-induced negative affect, focusing on myelination in the anterior cingulate cortex and the influence of norepinephrine.
Description
This project aims to understand the contribution of myelin to negative affective behaviors induced by fentanyl withdrawal and test whether restoring myelination can relieve these behaviors. The research will focus on the impact of fentanyl on myelination in the anterior cingulate cortex (ACC) and investigate the role of myelin loss on withdrawal-induced negative affect. The study will explore how norepinephrine (NE) influences myelination and oligodendrocyte precursor cell (OPC) differentiation during withdrawal.