Award
National Institute of Allergy and Infectious Diseases 5R01AI170784-04
Pharmacokinetic and pharmacodynamic relationships for antibacterial treatment of shigellosis
Recipient
University of Washington
Award Amount
$430,954.00
Ceiling
$430,954.00
Awarded
April 07, 2026
Identifier
5R01AI170784-04
Research grant to study pharmacokinetic and pharmacodynamic relationships for antibacterial treatment of shigellosis, aiming to optimize dosing and develop new therapies using innovative models.
Description
This project aims to determine the pharmacokinetic and pharmacodynamic relationships for antibacterial treatments of shigellosis. The study will utilize mouse models and hollow fiber infection models to evaluate the efficacy and resistance emergence of WHO-recommended antibacterials against Shigella spp. The goal is to optimize dosing regimens and support the development of new therapeutics.